renal Q: Neoplasms of Urinary Tract:

Neoplasms of Urinary Tract:

What is the number of layers of urothelium found in a “normal” bladder?

All of the following are true except:

A.      Von brunns nests contain a large central lumen with colloid material

B.      Cystitis glandularis is considered a normal variant of urothelium

C.      Von brunns nest are an example of reactive proliferation of urothelium

D.      Cystitis glandularis contain a columnar, mucus secreting cell lining

An Egyptian woman presents with squamous cell carcinoma of the bladder. What infectious agent are you suspicious she was exposed to?

What is the most common bladder sarcoma in adults vs kids?

Bladder cancer may occur due to direct extension from ___________+__________+_________

Fill in the chart:

	description	Hyperplasia	Pleomorphism	chromatin	mitoses
Grade1
Grade2
Grade3

Match the following: answers maybe reused/multiple

A.      Renal papillary adenoma

B.      Renal oncocytoma

C.      Angiomyolipoma

D.      Renal fibroma

                                I.            Epithelial neoplasm in which cells have abundant eosinophilic cytoplasm and small round nuclei. They have a high concentration of mitochondria

                              II.            Typically are very small and present within the renal medulla and have no malignant potential. Neoplasm shows fibroblast proliferation.

                            III.            Benign

                            IV.            Irregular and admixed proliferation of blood vessels, smooth muscle, fat

                              V.            Small (<1cm) – if larger than this generally considered RCC

                            VI.            Grossly: homogenous and brown with a central scar

                          VII.            Do not misdiagnose a granular RCC or chromophobe RCC as this!

                        VIII.            Composed of branching papillary fronds with fibrovascular cores

                            IX.            25% patients with tuberous sclerosis have this neoplasm

All of the following are true about RCC except:

A.      85% of all renal cancers are RCC

B.      There is a male predominance

C.      Tumors typically occur 40-50’s

D.      Unopposed estrogen therapy is a risk factor

E.       Most cases are sporadic

The three classic diagnostic deatures of RCC are: ___________+_____________+_________

·         You may also see signs of paraneoplastic syndromes such as:

Match the type of RCC with the description:

A.      Clear cell

B.      Papillary

C.      Chromophobe

D.      Collecting duct

        I.            Maybe associated with sickle cell trait – if so it is termed “medullary carcinoma” and is rapidly fatal

      II.            80% of all RCC

    III.            composed of pale eosinophilic cells with distinct cell borders and perinuclear clearing

    IV.            May see psammoma bodies when these tan tumors are examined histologically

      V.            These bright yellow tumors have a high propensity for venous invasion

RCC  is associated with  a loss of part of ______ chromosome in 98% of tumors. What syndrome is associated with this loss (resulting in a high co-incidence).

All of the following concerning urothelial carcinoma of the renal pelvis are true except:

A.      These tumors become symptomatic late in their course

B.      Patients may have gross hematuria and renal colic

C.      Up to 50% of patients have a pre-existing/concomitant bladder cancer

D.      Poorer prognosis than bladder carcinoma

What is the most common renal neoplasm of childhood?

This tumor has been linked to abnormalities with a TSG located on chromosome ___

This tumor is (histologically) composed of three main components

1.        

2.        

3.