Sunday, December 9, 2012

Chelsea Slade's Q set on Leukemia/Lymphoma!


Leukemias and Lymphomas! 

1.  What is the primary tumor-killing cell of the immune system?
            A)  CD4 cells
            B) macrophages
            C) CD8 cells
            D) NK cells
            E) plasma cells
            F) Chuck Norris

2.  Which statement accurately describes a mechanism used by tumor cells to evade elimination by the immune system?
            A) Tumor cells express more MHCI molecules, which lets them hide from T cells, but attracts NK cells
            B) Tumor cells express more MHCI molecules, which lets them hide from NK cells, but attracts T cells
            C) Tumor cells express less MHCI molecules, which lets them hide from T cells, but attracts NK cells
            D)  Tumor cells express less MHCI molecules, which lets them hide from NK cells, but attracts T cells

3-6.  Match the affected protein with the appropriate translocation:
            A) c-myc
            B) cyclin D1
            C) BCL2
            D) BCR-ABL

            3. t(14;18)
            4. t(8;14)
            5. t(11;14)
            6. t(9;22)

7.  Which of the following is not a type of B-cell NHL?
            A) Anaplastic large cell lymphoma
            B) Small lymphocytic lymphoma
            C) Marginal zone lymphoma
            D) Burkitt lymphoma

8.  Which type of lymphoma is most likely to exhibit a nodular growth pattern?
            A) HL
            B) Follicular lymphoma
            C) T-cell lymphoma
            D) B and C

9-16.  Match the lymphoma to its associated characteristic.  Each answer may be used once, more than once, or not at all:
            A) follicular lymphoma
            B) marginal zone lymphoma
            C) Burkitt lymphoma
            D) mycosis fungoides

            9. can be treated with antibiotics
            10. cerebriform nuclei
            11. c-myc
            12. made up of T-cells
            13. BCL-2
            14. t(14;18)
            15. EBV
            16. t(8;14)

17.  What is the most common type of NHL worldwide?
            A) follicular lymphoma
            B) marginal zone lymphoma
            C) Burkitt lymphoma
            D) diffuse large B-cell lymphoma

18.  Which type of cell is involved in Sezary syndrome?
            A) CD4 cells
            B) CD8 cells
            C) immature B cells
            D) mature B cells

19.  The Reed-Sternberg cell is an abnormal cell of which type?
            A) macrophage
            B) T cell
            C) B cell

20.  True or False: Hodgkin lymphoma is seen almost exclusively in elderly adults.
            A) true
            B) false

21.  Mr. Perkins, a 48yo man with hypertension and hyperlipidemia, is diagnosed with nodular sclerosing Hodgkin lymphoma.  Careful workup shows him to have involved nodes in the supraclavicular and inguinal nodes.  The spleen and bone marrow do not seem to be involved.  Mr. Perkins has not been experiencing any fever, night sweats, or weight loss, though he has had a chronic dry cough.  What stage lymphoma does Mr. Perkins have?
            A) Stage IA
            B) Stage IB
            C) Stage IIA
            D) Stage IIB
            E) Stage IIIA
            F) Stage IIIB
            G) Stage IVA
            H) Stage IVB

22.  True or False: plasma cell myelomas have a bimodal age distribution of incidence.
            A) true
            B) false

23.  Which of the following are common signs / symptoms of plasma cell myeloma?
            A) hypercalcemia
            B) proteinuria
            C) lytic bone lesions
            D) anemia
            E) infections
            F) two of the above
            G) three of the above
            H) four of the above
            I) all of the above

24.  Most common Ig secreted in monoclonal gammopathy?
            A) IgA
            B) IgD
            C) IgE
            D) IgG
            E) IgM

25.  Serum hyperviscosity is a common feature of which plasma cell dyscrasia?
            A) plasma cell myeloma
            B) Waldenstrom macroglobulinemia
            C) both
            D) neither

26.  Which leukemia is associated with the Philadephia chromosome?
            A) ALL
            B) AML
            C) CLL
            D) CML

27.  Which statement regarding leukemias is false?
            A) prognosis of acute leukemia is poor, except for childhood ALL
            B) proliferation of WBCs leads to reduced infections
            C) petechiae should prompt a workup for leukemia
            D) bone marrow biopsy is helpful for diagnosis

28.  True or false: APL carries a relatively favorable prognosis.
            A) true                         B) false

29. True or False: the leukocyte alkaline phosphatase score is increased in CML.
            A) true                         B) false

30.  Which leukemia will often show increased eosnophils and basophils in the bone marrow?
            A) ALL
            B) AML
            C) CLL
            D) CML

31.  True or false: CML can undergo an acute blast crisis and transform into either AML or ALL.
            A) true
            B) false

32.  Which of the following are features of polycythemia vera:
            A) increased EPO
            B) JAK2 mutation
            C) hyperviscosity
            D) two of the above
            E) all of the above

33.  Which of the following is primary myelofibrosis most likely to become if it undergoes a blast crisis?
            A) ALL
            B) AML
            C) equally likely to become ALL or AML

34.  Which of the following is not a feature of hairy cell leukemia?
            A) TRAP positive
            B) small number of hairy cells in peripheral blood
            C) good survival
            D) subtype of CML
            E) two of the above

35-40.  Match the following pictures to the appropriate diagnosis.  Answers may be used once, more than once, or not at all.
            A) AML
            B) ALL
            C) CML
            D) CLL
            E) multiple myeloma
            F) hairy cell leukemia
            G) Hodgkin lymphoma
            H) nodular sclerosing NHL
            I) Burkitt lymphoma

35. 


36. 


37.


38.

 

39. 


40.

 
ANSWER KEY

1.         Answer: C (see slide 21 of Neoplasia II)
2.         Answer: C (see slide 25 of Neoplasia II)
3-6       Answer: 3-C, 4-A, 5-B, C-D  (see slide 11 of Lymphomas, 8 of Leukemias)
7.         Answer: A (see slide 25-26 of Lymphomas)
8          Answer: B (see slide 27 of Lymphomas)
9-16     Answer: 9-B, 10-D, 11-C, 12-D, 13-A, 14-A, 15-C, 16-C (slide 32, 37, 38 of Lymphomas)
17.       Answer: D (see slide 35 of Lymphomas)
18.       Answer: A (slide 43 of Lymphomas)
19.       Answer: C (slide 45 of Lymphomas)
20.       Answer: B, false (slide 47 of Lymphomas)
21.       Answer: E (page 51 of Lymphomas)
22.       Answer: B, false (slide 55 of Lymphomas)
23.       Answer; I (slide 55 of Lymphomas)
24.       Answer: D (slide 58 of Lymphomas)
25.       Answer: B (slide 68 of Lymphomas)
26.       Answer: D (slide 44 of Leukemias)
27.       Answer: B Slide 15, 16, 17 of Leukemia)
28.       Answer: A, true (slide 31 of Leukemias)
29.       Answer: False (slide 40 of Leukemias)
30.       Answer: D (slide 43 of Leukemias)
31.       Answer: A, true (slide 45 of Leukemias)
32.       Answer: D (slide 46-47 of Leukemias)
33.       Answer: B (slide 50 of Lekuemias)
34.       Answer: D (slide 54, 61 of Leukemias)
35-40.  Answer: 35 – E, 36 – G, 37 – C, 38 – D, 39 – I, 40 – A

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