Leukemias and Lymphomas!
1. What is the primary tumor-killing cell of the
immune system?
A) CD4 cells
B)
macrophages
C) CD8
cells
D) NK cells
E) plasma
cells
F) Chuck
Norris
2. Which statement accurately describes a
mechanism used by tumor cells to evade elimination by the immune system?
A) Tumor cells express more MHCI
molecules, which lets them hide from T cells, but attracts NK cells
B) Tumor cells express more MHCI
molecules, which lets them hide from NK cells, but attracts T cells
C) Tumor cells express less MHCI
molecules, which lets them hide from T cells, but attracts NK cells
D)
Tumor cells express less MHCI molecules, which lets them hide from NK
cells, but attracts T cells
3-6. Match the affected protein with the
appropriate translocation:
A) c-myc
B) cyclin
D1
C) BCL2
D) BCR-ABL
3. t(14;18)
4. t(8;14)
5. t(11;14)
6. t(9;22)
7. Which of the following is not a type
of B-cell NHL?
A)
Anaplastic large cell lymphoma
B) Small
lymphocytic lymphoma
C) Marginal
zone lymphoma
D) Burkitt
lymphoma
8. Which type of lymphoma is most likely to
exhibit a nodular growth pattern?
A) HL
B)
Follicular lymphoma
C) T-cell
lymphoma
D) B and C
9-16. Match the lymphoma to its associated
characteristic. Each answer may be used
once, more than once, or not at all:
A)
follicular lymphoma
B) marginal
zone lymphoma
C) Burkitt
lymphoma
D) mycosis
fungoides
9. can be treated with antibiotics
10. cerebriform nuclei
11. c-myc
12. made up of T-cells
13. BCL-2
14. t(14;18)
15. EBV
16. t(8;14)
17. What is the most common type of NHL
worldwide?
A)
follicular lymphoma
B) marginal
zone lymphoma
C) Burkitt
lymphoma
D) diffuse
large B-cell lymphoma
18. Which type of cell is involved in Sezary
syndrome?
A) CD4
cells
B) CD8 cells
C) immature
B cells
D) mature B
cells
19. The Reed-Sternberg cell is an abnormal cell
of which type?
A)
macrophage
B) T cell
C) B cell
20. True or False: Hodgkin lymphoma is seen
almost exclusively in elderly adults.
A) true
B) false
21. Mr. Perkins, a 48yo man with hypertension and
hyperlipidemia, is diagnosed with nodular sclerosing Hodgkin lymphoma. Careful workup shows him to have involved
nodes in the supraclavicular and inguinal nodes. The spleen and bone marrow do not seem to be
involved. Mr. Perkins has not been
experiencing any fever, night sweats, or weight loss, though he has had a
chronic dry cough. What stage lymphoma
does Mr. Perkins have?
A) Stage IA
B) Stage IB
C) Stage
IIA
D) Stage
IIB
E) Stage
IIIA
F) Stage
IIIB
G) Stage
IVA
H) Stage
IVB
22. True or False: plasma cell myelomas have a
bimodal age distribution of incidence.
A) true
B) false
23. Which of the following are common signs /
symptoms of plasma cell myeloma?
A)
hypercalcemia
B)
proteinuria
C) lytic
bone lesions
D) anemia
E)
infections
F) two of
the above
G) three of
the above
H) four of
the above
I) all of
the above
24. Most common Ig secreted in monoclonal
gammopathy?
A) IgA
B) IgD
C) IgE
D) IgG
E) IgM
25. Serum hyperviscosity is a common feature of
which plasma cell dyscrasia?
A) plasma
cell myeloma
B)
Waldenstrom macroglobulinemia
C) both
D) neither
26. Which leukemia is associated with the
Philadephia chromosome?
A) ALL
B) AML
C) CLL
D) CML
27. Which statement regarding leukemias is false?
A)
prognosis of acute leukemia is poor, except for childhood ALL
B)
proliferation of WBCs leads to reduced infections
C)
petechiae should prompt a workup for leukemia
D) bone
marrow biopsy is helpful for diagnosis
28. True or false: APL carries a relatively
favorable prognosis.
A) true B) false
29. True or False:
the leukocyte alkaline phosphatase score is increased in CML.
A) true B) false
30. Which leukemia will often show increased
eosnophils and basophils in the bone marrow?
A) ALL
B) AML
C) CLL
D) CML
31. True or false: CML can undergo an acute blast
crisis and transform into either AML or ALL.
A) true
B) false
32. Which of the following are features of
polycythemia vera:
A)
increased EPO
B) JAK2
mutation
C)
hyperviscosity
D) two of
the above
E) all of
the above
33. Which of the following is primary
myelofibrosis most likely to become if it undergoes a blast crisis?
A) ALL
B) AML
C) equally
likely to become ALL or AML
34. Which of the following is not a
feature of hairy cell leukemia?
A) TRAP
positive
B) small
number of hairy cells in peripheral blood
C) good
survival
D) subtype
of CML
E) two of
the above
35-40. Match the following pictures to the
appropriate diagnosis. Answers may be
used once, more than once, or not at all.
A) AML
B) ALL
C) CML
D) CLL
E) multiple
myeloma
F) hairy
cell leukemia
G) Hodgkin
lymphoma
H) nodular
sclerosing NHL
I) Burkitt
lymphoma
35.
36.
37.
38.
39.
40.
ANSWER KEY
1. Answer: C
(see slide 21 of Neoplasia II)
2. Answer: C
(see slide 25 of Neoplasia II)
3-6 Answer: 3-C,
4-A, 5-B, C-D (see slide 11 of
Lymphomas, 8 of Leukemias)
7. Answer: A
(see slide 25-26 of Lymphomas)
8 Answer: B
(see slide 27 of Lymphomas)
9-16 Answer: 9-B,
10-D, 11-C, 12-D, 13-A, 14-A, 15-C, 16-C (slide 32, 37, 38 of Lymphomas)
17. Answer: D
(see slide 35 of Lymphomas)
18. Answer: A
(slide 43 of Lymphomas)
19. Answer: C
(slide 45 of Lymphomas)
20. Answer: B,
false (slide 47 of Lymphomas)
21. Answer: E
(page 51 of Lymphomas)
22. Answer: B,
false (slide 55 of Lymphomas)
23. Answer; I
(slide 55 of Lymphomas)
24. Answer: D
(slide 58 of Lymphomas)
25. Answer: B
(slide 68 of Lymphomas)
26. Answer: D
(slide 44 of Leukemias)
27. Answer: B
Slide 15, 16, 17 of Leukemia)
28. Answer: A,
true (slide 31 of Leukemias)
29. Answer: False
(slide 40 of Leukemias)
30. Answer: D
(slide 43 of Leukemias)
31. Answer: A,
true (slide 45 of Leukemias)
32. Answer: D
(slide 46-47 of Leukemias)
33. Answer: B
(slide 50 of Lekuemias)
34. Answer: D
(slide 54, 61 of Leukemias)
35-40. Answer: 35 – E,
36 – G, 37 – C, 38 – D, 39 – I, 40 – A
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