coagulopathy/blood product A

	PT	PTT	BT
Hemophilia A	-	increase	-
Factor 7 deficiency	increase	-	-
Factor 5 deficiency	increase	increase	-
vWF deficiency	-	increase	increase
Aspirin	-	-	Increase
Thrombocytopenia	-	-	increase
DIC	Increase	Increase	increase

heparin:

Warfarin: 

• what type of blood product is given for:
•  fibrinogen deficiency: cryopercipitate
• lacking multiple coagulation factors: fresh frozen plasma
• second line for vWF disease: cryopercipitate
• second line for hemophilia A: Cryopercipitate
• Hgb <7: packed RBC

• If an invasive procedure: how high do you want platelet count (>50,000)
• what if it is a neuro surgery (>100,000)

• How do I avoid/reduce the risk of the following reactions:
• acute hemolytic rxn: ABO match
• delayed hemolytic transfusion: good history of prior transfusions
• febrile non hemolytic rxn: leukocyte reduced (remove WBC)
• anaphylaxis - most common IgA def. recipient with anti-IgA AB
• TRALI - transfusion related acute lung injury: HLA match (antibody to HLA on WBC --- activated PMN accumulate in lungs --> microvascular occlusion and capillary leakage)
• circulatory overload: slow infusion, concentrate products/split units (ex: give packed RBCs not whole blood)
• septic rxn: proper storage / culture platelets
• graft vs host disease: Irradiation (prevent proliferation lymphocytes)