L9a

Describe what you see in the picture:

There is an increase in cellularity with a nodal architecture. The nodes are separated by broad collagen bands.

Note: Reed-Sternberg cells (these are necessary for a Dx of HL) in a hylanized background. There is a mixed inflammatory background composed of lymphyocytes, plasama cells, histiocytes, eosinophils (not all are evident in this slide -- see below).

·        What kind of HL is seen here? Is this type seen more commonly in men or women? 

•       Nodular sclerosing HL

At what age do people typically present with HL? How do they present?

•          Bimodal: 15-35, >45
•            Younger patients present with localized disease and minimal symptoms while older patients tend to present with disseminated disease and “B” symptoms

What are the classic forms of HL (list from those with best prognosis to worst)?

•        Nodular sclerosis Hodgkin lymphoma – 70% of CHL

•        Mixed cellularity Hodgkin lymphoma – 20% of CHL

•        Lymphocyte-rich Hodgkin lymphoma – 5% of CHL

•        Lymphocyte-depleted Hodgkin lymphoma – <1% of CHL

What virus are they associated with? EBV

If a patient presents with a cervical and an inguinal node what stage is she? 

Stage 3: involvement of more than one LN/extranodal site on opposite sides of the diaphragm