L1

Mr. Brown presents to the office with a fever. He tells you that in the past two months he has taken many sick days. “I keep coming down with something. It seems as soon as I beat one bug there is another one I get right away. I am tired all of the time!” He has complaints of fatigue. At this appointment you notice that his skin looks very pale and he has several large bruises. 

Bone marrow Aspirate:

What is the arrow pointing to?

·         What translocation would support your diagnosis?

·         Assuming Mr. Brown has this translocation what would you use to treat him?

·         Which of the following are positive cytogenetic markers for AML? ALL?

o   8;21

o   6;9

o   15;17

o   Hyperdiploidy

o   9;22

o   12;21

o   16q22 break

o   Inv(3)

o   1;19

o   11q23 break

·         What are some of the risk factors for AML?