N1

A 49 year old woman presents to the office after her PCP noted a nodule on her thyroid. Although her thyroid was diffusely enlarged last visit - the nodule is new. It is noted in her chart that she was exposed to radiation as a child.  She notes that “it feels like something is stuck in my throat.” She has a dry cough and some difficulty swallowing.

This is from a previous biopsy of the patients thyroid: What does she likely have a history of?

gross specimen of Thyroid from a patient with the same Dx as our patient

If you were to palpate her neck what would you expect to feel?

Describe the histologic findings:

What is the Dx?

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What are three ways tumors tend to spread? How about this type in particular?

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Activation of which protooncogene is associated with this type of cancer?

What in her history puts her at risk for this type of cancer?