Neoplasia Quiz

1.       Which of the following is found in benign tumors?

·         Undifferentiated cells

·         Pleomorphic cells

·         Capsule

·         Invasive growth

·         Many mitotic figures

2.       All of the following are features of malignant tumors except:

·         Metastases

·         Necrosis

·         Hemorrhage

·         Low N:C ratio

·         Prominent nucleoli

3.       What are the three major ways tumors metastasize?

1.

2.

3.

4.       For a malignant tumor to metastasize and survive at the new site it needs to elicit

·         Anaplasia

·         pleomorphism

·         Angiogenesis

·         Carcinogenesis

5.       How do you name a benign tumor of mesenchymal origin?

6.       What is the origin of a leiomyoma

·         Fat

·         Smooth muscle

·         Striated muscle

·         Epithelium

7.       All of the following are mesenchymal tumors except:

·         Fibroma

·         Liposarcoma

·         Hemangioma

·         Adenoma

·         Leiomyosarcoma

8.        

This is from a biopsy of a uterus – what type of cancer is this?

·         Epithelioma

·         Transitional cell papilloma

·         Adenocarinoma

·         Meningioma

9.       What are the three leading cancer types in men (in decreasing order of occurrence)

·         Lung > colon > prostate

·         Prostate > lung > colon

·         Melanoma > lung > prostate

·         Colon > prostate > kidney

10.   What is the inheritance pattern for BRCA 1? If they inherit the gene will they 100% get cancer?

·         AD , yes

·         AD, no

·         AR, yes

·         AR, no

11.   People with the following disorder are unable to repair DNA damage from UV light and therefore are at increased risk for skin cancer:

·         Bloom syndrome

·         Ataxia-telangiectasia

·         Xeroderma pigmentosum

·         Franconi anemia

12.   Familial cancer is characterized by all of the following except:

·         Early age of onset

·         Multiple or bilateral tumors

·         Marker phenotype

·         Family history in 2+ close relatives

13.   Cardiac muscle shows box-car nuclei on histologic exam and grossly it looks enlarged. This is an example of:

·         Hyperplasia

·         Hypertrophy

·         Metaplasia

14.   Tumors are greatly dependent on their stroma for growth. Some tumors have scant stromal support while in others the tumor cells stimulate the formation of a dense, fibrous stroma. This is  termed

·         Stromoplasia

·         Dysplasia

·         Desmoplasia

·         Anaplasia

15.    Mix and match

1.       Papilloma 2.       carcinoma 3.       Adenoma 4.       sarcoma 5.       Hamartoma 6.       lymphoma

·        Mesenchymal tissue (M) ·        Epithelial tumor derived from any of the 3 germ layers (M) ·        glandular pattern (B) ·        disorganized mature specialized cell indigenous to a particular site (B) ·        Finger like projections(B) ·        hematopoietic tumor (M)

16.    Which of the following is true of promoters?

·         Their actions are reversible

·         A promoter can cause cancer in the absence of an initiator

·         The effect of a promoter is NOT time dependent

·         Promoters cause DNA mutation

17.   What is the most common type of tumor to form after exposure to radiation?

·         Breast cancer

·         Leukemia

·         melanoma

·         Thyroid cancer

18.   A 17 year old girl presents to your office with HPV - 6. Is this type of HPV low risk or high risk? What clinical manifestation is associated with this type of HPV?

·         “low risk” à genital warts

·         “high risk” à genital warts

·         “low risk” à Squamous cell carcinoma

·         “high risk” à squamous cell carcinoma

·         “low risk” à adenocarcinoma

·         “high risk” à adenocarcinoma

19.    EBV is associated with all of the following types of cancer except:

·         Burkitt lymphoma

·         Hepatocellular carcinoma

·         B-cell lymphoma immuno-suppressed

·         Nasopharyngeal carcinoma

20.   Patient presents with chronic atrophic gastritis and duodenal ulcers. The symptoms improve after the patient is treated with antibiotics. What forms of cancer are you concerned they could have developed if they had not sought treatment? __________________  & _______________________________

21.   Mix and match

1.       PSA 2.       B-HCG 3.       AFP 4.       CA-125

A.      Ovarian B.      Prostate C.      Non seminomatous testicular D.      hepatocellular

 22.   All of the following are associated with tumor grade except:

•         Cell size/shape
•         N:C
•          Mitotic activity
•          Metastasis
•         Organization of tissue
•         Lymphovascular invasion
•          Necrosis